If regional sympathetic blockade provides relief, surgical sympathectomy can be considered. Initial pain relief may be significant, but symptoms tend to recur over the next 2 to 5 years.[53] This is believed to occur owing to incomplete surgical removal of all sympathetic innervation to the extremity. Collateral reinnervation can occur, but bilateral sympathectomy may cause bowel, bladder, or sexual dysfunction.[14]
It is possible to disrupt the sympathetic chain ganglion by treatments other than surgery. Ablation with radiofrequency devices and caustic chemicals (such as alcohol) have been described, but the region of necrosis may expand beyond the ganglion and long-term results are unknown.[59,][69] As such, surgical sympathectomy is considered strictly as a last resort.
Knee Disorders: Surgery, Rehabilitation, Clinical Outcomes By Frank R. Noyes, MD