Results: Mice treated with PDGF inhibitor AG 1296 showed an inhibition of corneal neovascularization and a reduction of pericytes in the new formed vessels compared to untreated animals.
Retina from sympathectomized eyes receiving saline treatment had significantly reduced PEDF mRNA and protein expression relative to the contralateral eye receiving saline treatment. These results are similar to previous work and indicate that injection alone did not alter the results. Intravitreal PEDF administration to sympathectomized eyes returned both mRNA and protein levels to those of the contralateral eye. PEDF administration also normalized retinal morphometry to prevent the sympathectomy-induced increases
in capillary density of the outer plexiform layers, as well as the ganglion cell layer.
Conclusions: These results suggest that one injection of PEDF can restore protein and mRNA
levels to those noted in an untreated animal. Furthermore, these results also indicate that
one injection of PEDF can reverse the morphological changes noted after sympathectomy
in the retina.
CR: J.J. Steinle, B.L. Lashbrook,
files.abstractsonline.com/SUPT/25/1421/SessionPDF/119.pdf